B12 Tx

Cyanocobalamin is the synthetic form of vitamin B12
Cyanocobalamin is the synthetic form of vitamin B12 and is broken down by the body into methylcobalamin and toxic cyanide, which can cause strong allergic reactions in some cases. This artificial form has been leading the US market in B12 supplements for many years, primarily because it is easy to manufacture. Increasingly, however, it is becoming a less popular as its disadvantages are more widely acknowledged. Some even argue that the product should be taken of the market entirely, as it is so inferior to other forms.
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  • Dr. Robert Ambrozic MD
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  • B12 Tx
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  • Up to 95% Replenishment
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  • The Natural Form
  • Hydroxocobalamin is one of the natural forms of vitamin B12. It can be produced by a number of bacteria. The body must first convert hydroxocobalamin, but in contrast to disadvantages of cyanocobalamin, it has the advantage of staying in the body far longer and not being excreted so readily. Hydroxocobalamin is currently the international standard for vitamin B12 supplements and is also the drug of choice as recommended by WHO.
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  • Our personal recommendations for vitamin B12 when used for medicinal purposes are methylcobalamin and adenosylcobalamin, which are both readily bioavailable. Both cyanocobalamin and hydroxocobalamin must first be converted into methylcobalamin and adenosylcobalamin before they can be used in the body. These forms are referred to as B12 coenzymes or bio-identical vitamin B12 forms.
What is B12?
Vitamin B-12 belongs to the family of cobalamins. It is available in all animal-derived foods, and is absorbed at a rate of 5 mcg per day. After being ingested, vitamin B-12 becomes bound to intrinsic factor, a protein secreted by gastric parietal cells. The vitamin B-12/intrinsic factor complex is absorbed in the terminal ileum by cells with specific receptors for the complex. The absorbed complex is then transported via plasma and stored in the liver.
Intestinal Malabsorption?

Since the liver stores 2,000 to 5,000 mcg vitamin B-12 (adequate for up to 5 years), dietary deficiency of cobalamin (Cbl) is rare. In most cases, vitamin B-12 deficiency is due to an inability of the intestine to absorb the vitamin, which may result from an autoimmune disease that reduces the production or blocks the action of intrinsic factor, or from other diseases that result in intestinal malabsorption. The most frequent underlying cause of vitamin B-12 deficiency is pernicious anemia, which is associated with decreased production of intrinsic factor.

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